if you really mean replace and are willing to ditch one of the origional clips then yes, and if you have corresponding code…I’ve done this a while back, not in front of machine now but…
ditch or unlink the media within the origional master clip, then reconform/reload/relink the replacement clip to the origional.
Though it really should be available as a function rather than a workaround, being able to replace a master clip with a multicam group would also be a great feature.
amheus