From my experience in saving project files with Adobe Photoshop, Vegas PRO and a couple of times in Adobe After Effects, I always have my apps installed on my main drive and every drives outside of the main SSD/HDD drives of your Windows OS are extra drives you can use for partitioning and storage. So as long as you have the app in Windows in general, it does not matter which drives you store it at as long as you have access to it.
If you have a lot less storage on your main drive than your 2nd SSD drive, its much better to store it on your 2nd drive because if you have too many projects on your Windows OS drives, it can slow down the operating system over time. For me I store my projects in a Cloud storage but it stores on my main drive so it really all depends on the storage capacity on each.
Here is also a video I found that can explain more on this situation: https://www.youtube.com/watch?v=0ZxqAlDwSDI
Some contents or functionalities here are not available due to your cookie preferences!
This happens because the functionality/content marked as “Google Youtube” uses cookies that you choosed to keep disabled. In order to view this content or use this functionality, please enable cookies: click here to open your cookie preferences.