Yeup if you are getting the big orange block or chequerboard appearing then something is up with your media.
It has happened to me, a file gets corrupted, Photoshop files get saved in the wrong format or just me being dumb and forgetting to hit save on something.
Try duplicating your project and then remove half the different media in each. See which one crashes. Then do the same again with the crashed project (OK, 2 and 3 files) etc
Just one thought, have both your machines got the same graphics card?
HTH
Peter