There is no magic preset for all scenarios. Understanding how compression and compression applications work is necessary to get the best results.
Presets are usually a good place to start, but an even better starting point is learning about the subject. There are a number of books on the subject, but one of the best resources is
Internet Killed the Video Star by Aharon Rabinowitz
A Guide to Creating Video for the Web. It is a great 4.5 hour DVD available at the Cow Store.
Or try this;
In the Adobe Media encoder choose H264 as the Format and “Apple Ipod Video Large” as the Preset. Change the “Bitrate Encoding” setting to VBR 2 Pass. Premiere is not as good at this as Procoder or Squeeze.
https://www.video2stream.com