Hi Peter,
Yes, It should be pretty easy, I generally render out my 2D animation from AE as a quicktime movie (most people use a .tif, or .png sequence, I just prefer the .mov. your choice). Create a texture and put the .mov or sequence into the color channel (you can put it into the luminance channel if you don’t want it effected by lights). In the animation tab, you can set your frame rate etc. I’m pretty sure that defaults to the frame rate of the movie. There are some other options in there for looping, frame range etc. You can mess around with that to your liking. For more interest, you could then render out some items in 3D as a separate layer to give the illusion things are jumping off of the page etc.
Good Luck,
Mike