Learn keyboard shortcuts.
I think the default keys for A1,2,3,4 are nine, zero, minus and equals (I have them remapped to one, two, three, four because it makes sense to me).
Turn ‘autopatch’ on ( https://bfy.tw/1SnS )
Now, if you leave V1 and A3,4 selected in your timeline – loading a new clip will be set to a default patch, with all tracks enabled.
As you have loaded a clip in the source monitor, it has focus, so your keyboard commands for A1,2 will deselect those buttons and autopatch will patch the remaining tracks (A3,4) to the currently enabled timeline tracks (A1,2).
You can use deselect all (Cmd+shift+A) to help get either side to a blank slate.
There is a setting to recall selected tracks when clip is loaded – I prefer to have this on, not sure what the default is.
Here’s a video I made a few years ago to try and encourage Adobe to be ‘inspired’ by autopatch. No luck yet https://www.dropbox.com/s/sy71wfce2tksgbg/detailed%20autopatch.mp4?dl=0