Hi Diego,
Let’s say that the interview is 2 hours and your first cut is 50 minutes. If you don’t have any markers and you want to find a specific subject of the speech in your edit sequence, since you have cut it down and lost the timecode reference with your transcription it will be difficult.
Also if you take a two minutes area, make it disable and later in your edit make this area half then you will be lost.
Fix it in Pre.