The High profile delivers enhanced quality over main. The tradeoff is it’s more complex, which means it is harder for devices to decode. Back in the day you may have had to use baseline for certain devices and main was used for SD digital broadcasts. When the High profile was developed, it became recommended for HD applications. Over the years, more and more devices are able to decode this profile.
The encoding level that is selected dictates the choices you’ll have for settings like max resolution, decoding speed, frame rate, bit rate, etc. For example, one of the main differences in 4.2 versus 4.1 is a doubling of the maximum decoding speed.
In either case, just double-check the constraints of the whatever the decoding device will be. I assume you are using Adobe Media Encoder and they have many presets to choose from that have optimal settings. Or, if you bring in a clip for compression and select match source, they will set the profile and level. However, I notice it’ll usually default to main and 4.1 but I’ll bump it up to high for many of my project needs/requirements.
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