there are like always several approaches possible…
but i would say prores4x4 is fine, even considering various generations. in my experience you
don’t really see a degradation, but if you zoom in and focus on a specific part of a frame you
might be able to see that the “grain” differs somehow on the second generation, on a pixelbasis though.
that’s why they call it visually lossless i think. never had a realworld degradation when going threw vfx.
and prores is resolution-independant, so you can still leave resolution intact.
and you can consider doing a base-grade to avoid throwing some black or white info away f-stopwise,
or go the log way.
just my fast two cents!
andy