It really depends on the 4K you want to work with. 4K prores maybe, I think the bit rate is around 250MB/sec. If you wanted to do 4K openEXR probably not. Two reasons here 1. Bitrate is around 1,500MB/sec and you’re asking a spinning drive to get 24 or more files a second.
I know Local Hero Post in LA has a openEXR workflow and they rent a creative.space system so they can get the speed and IOPS for a 4K workflow.
Other concerns could be wanting to add more space, others be able to connect, and data integrity.