Hi Jeff,
I’ve got the exact same bug as you. AE most of the time loose real time playback. I’m on Windows 10 too. I’ve tried every versions of AE but since CC2015 the bug is still present (I don’t have any trouble with CC 2014).
My monitor is a BenQ BL2711U, what is yours ? Did you find a solution to solve the problem ?
Stephane.