The best work around is:
1. Copy all the stuffs inside “Objects” window.
2. Create a new empty file and save the empty file in the same directory as your current one so that all textures are linked correctly.
3.Paste the stuffs in the new file. All shortcuts should work now.
This happens to me a few times. File is corrupted and there is no other way to fix it except copy and paste all objects in a new document.