eSATA is the cable connection type. Make sure everything is SATA II (or 300) – Card, drives, and enclosure if you go this route.
What is new is stuff like the Fusion D800RAID which are Mutlilane ports these are more expensive and you need matching cards but they are the faster systems. Seems like you get the same speeds at RAID 5 and with SATA II at RAID 0.
If I where doing Uncompressed multi cam I would get the fastest set up. The keywords are multilane or SAS connectors if you want to research them. There are several post on in this and other forums.