Here’s an attempt in that direction in Photoshop. The render looked suspiciously like Anna Faris, so I found an (unretouched) photo of her and used some bad photo retouching methods to get some of the human realism out of her, so that she would look more synthetic. Overdo the noise reduction in the skin, unsharp mask to bring out unrealistic amount of edge clarity elsewhere, use shadows and highlights to add some HDR-style lighting, make the colors a bit unnaturalistic and then overdo the white in her hair to take it outside the believable range. All filter-based, no manual retouching involved. So that’s one possible approach. Before and after for comparison.

Kalleheikki Kannisto
Senior Graphic Designer