sorry for the typo, i meant to say thunderbolt 2 is much faster than thunderbolt 1.
-The disk cache is not used for RAM previews.
Standard preview (commonly called spacebar play) plays video in the active Composition, Layer, or Footage panel from the current time. Standard preview does not play audio.
Standard previews play at a speed as close to the speed of real time as possible. However, for complex compositions, the speed of the preview may be much less than real-time speed.
“After Effects does not cache frames that require little time to render. Frames remain uncompressed in the image cache.”
https://helpx.adobe.com/after-effects/using/memory-storage.html#main-pars_heading_13
you also need to check your Maximum Disk Cache Size setting.
In After Effects CS6, the default disk cache size is set to 10% of the volume’s total size, which 250gb at 10% = 25gb
is the exact size limit you are experiencing.
and maybe you have secret-purge every x frames turned on!