Just render out your comp without the effect, then import it back in then apply the effect to it then re-render.
I don’t know exactly what your doing so I couldn’t tell you what the problem is. But you may want to eliminate certain features as a mean of troubleshooting. for example eliminate 3d functionality, try pre-composing instead of adjusctment layers, remove certain effects, allocate more memory, shut off certain layers, shake your computer tower.
Andrew