Try uninstalling Sapphire:
On Windows: go to Start->Control Panel->Add or Remove Programs. Find ‘GenArts Sapphire Plug-ins’ in the list, and press the Change/Remove button.
On Mac: go to the /Applications/GenArtsSapphireAE folder and double click on Uninstall Sapphire.
Then do a search of your hard drive for any additional files with “genarts” or “sapphire” in them and delete these.
You should then re-install the software and things should run ok