I’m seeing the same problem.
Left mouse button stops working when the computer wakes up, both mighty mouse as well as trackpad on MBP. Right click works OK. Need to reboot to recover.It does not happen every time.
Problem started recently (2-3 months back?), but I’m not sure what exact upgrade caused it.
Does anybody have any further details what could be causing that and how to fix it?
Thx,
Robert