First thing I would do is uninstall all things Matrox and see how everything runs in a native Adobe timeline. Do a full uninstall. All the utils and the cards pulled from the box. I was a loyal Matrox user for years (DSLE thru AXIO CS4) and by the end things were so buggy that I just turfed it all when I got a new CUDA card and never looked back.
Taking all that stuff out is a hassle to be sure, but it’s a real quick way to eliminate a bunch of possible causes.