They typically aren’t the same, because many de-noise audio plug-ins require some section without talking in order to calculate a noise print to remove that sound from under the dialogue. The better option is to send the audio clip to Audition and use its tools to clean up the track. Then bounce it out (processed and rendered) as a separate clip to use back in Premiere.
Other plug-ins like de-essers and so on on can probably be used on either clip or track. From a workflow standpoint, it’s best to group similar sounding clips onto separate tracks and then do all of your processing on the track, not individual clips. For example, A1 – SOT dialogue, A2 – VO, A3 – SFX, A4- music.
– Oliver
Oliver Peters – oliverpeters.com