Hi Lachlan,
I would say it depends on the job; I have two similar keyboard shortcut layouts I swap between, depending on whether I am doing VFX or AE work.
You definitely want to become familiar with the alternate functions for marking/navigation when holding down ALT, which can save some headaches while you are getting used to the way patching works.
I also have Add Edit, gang source/record, and Extend edit mapped in, since I use those a lot. And if you’re doing a lot of string outs or bulk edits, turn on edit from bin (which isn’t a keyboard shortcut and you didn’t ask for advice, sorry).