I have similar errors and audio popping problems. They tend to be more prevalent when I am running low on RAM and generally taxing the system at more than a minimum amount. This is with playback of HD MXF files (50Mbit XAVC) on a 2013 MacPro 6×3.33, 32GB RAM, off an OWC 4TB Raid 0 Thunderbolt enclosure.
I suspect having a separate scratch drive for the audio would solve the issue but I have not tried it yet.