Depends on how far in you want to zoom. If you want to extract an HD frame from the 4K image or do like a 25% zoom in for a reframe. For offline, it will be up to your tolerence as well as your source footage, but I find that in many case, zooming in is not that bad for creative editorial when all dailies are at HD resolution.
Here is an example of a 4K (4096×2304)16:9 image with an HD extract using both FrameFlex on a DNxHR LB version of the 4K frame, and again as a 25% resize on a DNxHD 36 transcode of the same frame:
Original image showing HD extract in FrameFlex

I then transcoded the original 4K image to DNxHD 36, then applied a 3D Warp and resized it to same parameters. I exported both as DPX so as to not introduce any further compression, then did a side by side in Photoshop at 100%. Hard to tell at 100% a whole lot of difference:

The same images in Photoshop now zoomed in at 200%. It is easier to now see some of the compression and resize artifacts:

If you do more typical resize type work, I did the same test again but only with a 75% extraction in FrameFlex compared to a 25% resize in DNxHD 36 using 3D Warp – here’s what it looked like in FrameFlex:

And then the exported frames comparing them side by side in Photoshop at 200% zoom in:

So as you can see, the impact may not be as server as you think it might be. And if everything is going to be conformed in Resolve or other third party, the AAF will carry the resize and the conform application will have the same resize applied as with Resolve, in my opinion, use a better resize algorithm.
If making Avid media in Resolve first, please make sure you have REEL properly set. It is best to use “use clip filename” in “conform assist settings in Resolve.
Michael