The media has no issues going back and forth, same for projects and bins. Your only consideration is mounting drives back and forth between PC and Mac.
I have now started using exFAT formatting as I am on 10.6.6 on Mac, and Win7 on my PC. There is no need for additional software on either side to mount HFS or NTFS and it does not have the drive size limitation of FAT32. Perfect for transporting back and forth.
Michael
Michael Phillips