almost same problems here , 390x oc asus card on windows 10 .. no luck till now( tried asus driver, amd crimson driver ) . the flickering/blinking appear only in split screen preview with gpu acceleration on. beside this ..lots of randomly crashes with gpu accelerated fx and dual set-up monitor with the second monitor used on onboard intel gpu or second gtx580 card. but sometimes it work ..fast .. very fast .. have no idea why and how to fix it yet .