Make sure that they are compressed with “ZIP16” (also refered to as ZIP). “ZIP Scanline” is default in many compositing programs (also refered to as ZIPS). There should not be much difference in file size it’s just wether or not it’s compressed 16 lines at a time or single lines. However since Davinci is limited in the amount of threads it uses when it’s decoded it gets a huge performance hit when using Zip scanline.
B44 is another option, however that is loss compressed (in theory).
We’re using ZIP16 and get great performance with even 2.5k.