No other cards installed in the MacPro. This is pretty much out of the box, the only other external devices that are being used is 1 or 2 Western Digital harddrives. Again, I’ve used the hard drives with the Mbox previously on the G5 without any problems. The system has been running fine the last couple days without the Mbox attached. I have done a complete reinstall from the master disks early but continue to have the problem. I’ll try trashing the preferences again… maybe something becomes mixed up when the CoreAudio 742 is installed.