I don’t know if that audio drive is the problem. I was working with Red Raw dragon footage at 4K and when I changed my drive and input the crashes mostly stopped. I had tried may different things to get my system running well trashing plugins, uninstalling all Black magic video drivers, Uninstalling and re-installing Premiere. And the drive change worked for me. You can try opening your Sequence in a new Project and I would also clear the cache.
The only other time I have had ton of trouble with a project if is I get it from someone else and it has plugins not in my system even if they are not in a sequence I am working on.
Another good resource is https://www.digitalrebellion.com/promaintenance/
The crash analyzer is very helpful.
Good luck.