I am able to run AE on Vista just fine, although my system currently runs XP faster. However, keep in mind that since Vista was just released, driver/app support is not quite there yet. Once the drivers/apps mature, Vista will look a lot more attractive–especially the 64-bit version, which will be able to take advantage of large amounts of memory with compatible 64-bit apps.
I can run everything I need to on a PC; some people need/want a Mac–it’s just personal preference. The new Mac Pros are a great way to get the best of both worlds.