first off, there’s no such thing as YUV lossless. it averages the rgb into overall brightness. second, interpret your incoming files so that they have correct color management into another correct project setting. Many files get saved with wrong color metatags in video imports. This goes for AE as well as quicktime players.
and also, moving from SDTV to HDTV color is lossy, it goes from YUV to YCbCr.
The main rule is: keep in same color space, color codec, and color bits.