I’m using Premiere CS5 on Windows 7, i7 Quadcore with 16 megs of RAM, 2T Raid 0, and an approved nVidia graphics card and I’m also getting the red screen glitch. It lasts anywhere from 2 frames to 2 seconds and it seems to knock the audio out of sync by about however long the glitch is. It happened on an event that was shot in HDV on a Sony Z1 so the system has plenty of horsepower. Fortunately it hasn’t caused me to crash or lock up. Video looks great when the MPEG is played back with, say Windows Media Player, but shows up in the same place everytime when using Premiere. I’ll try your solution but frankly our problems sound a little different albeit similar symptoms. I’m blown away that no one here has a solution. It’s obviously been around for several generations of Premiere. One thing I did notice: my original footage is on a portable drive. I reloaded the footage onto the RAID and a few of the spots where I was getting the glitch… shifted. I haven’t gone to tech support yet because I feel pretty sure everyone will point at everyone else.