I always use the Combo Updater, too. However, there seems to be a permissions problem with the Combo Update this time. If you Repair Permissions after installing the v10.5.8 Combo Update, in the list of repairs, you can note that a lot of files are having their permissions changed to ?——— and that might not be a good thing.
https://discussions.apple.com/thread.jspa?threadID=2106528&tstart=0
FWIW.
Brian Conner