16-235 is the consensus for broadcast.
Most of us run the levels effect to bring things down to that. However, it’s not always necessary if the colours in your design are alrady safe. To check, change your comp’s background to some garish green colour, then run the broadcast safe filter, “keying out unsafe” in an adjustment layer above the whole comp. Look through your entire program, and if it’s mostly unsafe, run levels, but move the effect before (above) the safe filter in the effects stack. That way, the safe filter is checking the colours after you’ve run levels. Once satisfied, switch off the safe filter.
However, if you can change your colours directly (say, in a piece of AE text) and you only have one bit of offensive red in the show, don’t run levels on the whole thing. Just change your red so it’s less saturated — but you might have to run the safe filter until you get to know what is a safe, less saturated red.
And here’s a tip from Frank Capria: If a yellow is unsafe, try adding a bit of red to it so it moves toward orange a little. That’ll make it safe without desaturating it toward yucky green.
Steve