It looks like to me that its a missing file in that directory where its pointing out. Did you remembered at any point if you accidently deleted an important file within like the Adobe folder? Or misplaced a file to another place? I think also using Windows Event Log can give you more information on what caused this error from Adobe After Effects. If it continues, you may have to uninstall and reinstall AE while keeping the .aep files in tact so when you reinstall it, perhaps all the files required to run AE will all be there for you to use. You should get access to your project file afterwards. I hope it helps! 🙂

Do you have an auto save folder?

You probably already have done this, but just open up the most recent project from the autosave folder.