[Walter Owen]

7 years later, I’ve found the solution for probably most of us here.

I signed up after having the problem myself, to post the solution here for anyone who landed here via search-machine.
Everything posted before, did not help in my case.

The solution is “Proxy Editing”.
Search for the term in Youtube and you will find plenty of introduction videos for Premiere CC.

Follow these steps:
– Copy all your clips onto your SSD (not HD)
(if you don’t have a SSD, the below steps will still help, but won’t completely eliminate stuttering)
– Create new project
– Under “Ingest Settings” chose “Ingest” and select “Create Proxies” in the drop down menu; Chose preset “1024×540 GoPro CineForm”
– Create Project with these settings
– Go into media browser window and look for your videos on your hard drive (remember SSD!)
– Select all videos, right-click and chose “import”
– Media Encoder opens automatically and renders all videos in this 1024×540 format and drops them into your project folder; wait for it to finish
– Go into the “Project” window and select all your clips, right-click, chose “create multi camera source sequence”
– Do your preferred multi-cam settings and apply
– right-click on just newly created sequence and chose “new sequence from clip”
– Press Shift+0 to go into multi-cam window-view
– click on the wrench symbol and search for the “Toggle Proxies” symbol. Drag and drop this symbol onto your shortcut-bar below of your multi-cam window
– click on the “Toggle Proxies” symbol to activate
-> Multi-Cam now plays without stuttering, even with 12x 1080p clips in my case