You should never use MPEG-2 twice – it’ll always lower the quality. But what kind of change do you need? If you need to shorten, insert or something like that, and if a precision of one quarter of a second is good enough, why don’t you edit in the timeline of DVDSP? While this is definitely not a MPEG-editing software, you’ll get away with minor corrections.
Regards,
Uli
Author of “DVDs gestalten und produzieren”, a book on professional DVD-authoring in German.