Thanks for your response Jeff.
Media is totally mixed. I work with an ever changing type of formats. .mp4 .mov .mxf – the last edit i worked on had media from minicams, f5, fs700, GoPro, 5D, GH4.
I have a range of machines; Latest MacBookPro Retina (top spec), Latest iMac (top spec), and a 2012 Mac Pro. All of which struggle.
Sequence settings is a good question. Often i drag the media into the new sequence option to set those up. I edit all sorts of media but will always go with the primary camera.
Mainly wondering if when people use mixed media they convert to something like ProRes to unify the formats which presumably cut Premiere some slack.
Thanks and I look forward to more people sharing their experiences.