[Tim Ware]

[Brian Charles] “Unknown, how soon After Effects will have a retina version. Since the UI in After Effects has been developed for lower resolution displays, the current version will appear to have very tiny UI elements (buttons, text widgets). It will likely be possible to change the resolution on the retina display to 1440 x 900 until there’s a retina update to After Effects though this is yet to be confirmed by Apple.”

This is the most painful thing when you’re used to having a large UI. Directing your mouse to tiny tiny icons is a nightmare.
As display resolutions keep getting higher this issue will keep getting worse, and Adobe need to do something about it. I’m an InDesign/Photoshop/Illustrator user.