Thanks for your response.
FW800 running a ProResHQ 10min short with instances of 3 clips on top of one another plays back through my blackmagic fine.
Copied a ProRes sequence that was on the 2TB hard drive in question onto the Macintosh HD and it played back fine. I scrolled through lots to try to make it drop frames but it didn’t.
Then went back to the project on the hard drive that had had issues and it was suddenly playing fine.
Ran Blackmagic Speed tests and got these results.
Mac HD (No dropped frames so far) – Read 124.2 MB/s Write – 120.9 MB/s
2TB Seagate (occasional drop frames on ProRes) – Read – 127.7MB/s Write – 118.4 MB/s
Maybe I’m being a bit panicky because I just spent so much on a new machine and I expected flawless playback of ProRes and ProRes HQ.