Dwaine,
I’ve tried CUDA 6.5.18, 6.5.14, and just now 5.5.47. As far as I’ve been able to tell, nobody has reported success with CUDA and Yosemite, no matter what the application. If you hear of a working set of drivers, please post here.
My system: MacPro 5.1, GTX 970, Nvidia web driver 346.01.01f3 (released today), and CUDA driver 6.5.18.
CUDA is unavailable in all apps. The CUDA preferences panel says “Update Required” and also says “No newer CUDA driver available”. Go figure.
Mike