Thank you for your response! I may have been mistaken in attributing any shortcomings to the file format itself as it’s likely just a limitation of After Effects, but the quality of MXF files naturally makes them rather large, and it seemed to bog down my system substantially more to process all that data with effects such as keylight and color correction than on a similar file in a smaller format. Given that I’m running a Core i9 with 64 gig of ram, I assume it’s not a hardware bottleneck?