Glad it helped.
If indeed your issue is/was GPU/CUDA related you may pinpoint it by checking at time of problem occurrence:
A1. Change/Update in GPU drivers (~or roll back to previous week)
A2. Change/Update in Premiere Version. (“~”)
Many times, the time consuming process of downloading many drivers (either previous Sub version ie. 395.75 and not 395.78 or Previous Version ie. 394.83 not 395.78), may help to get a stable platform, at least for your current workflow.
A good practice is to have auto-updating of drivers, software and OS disabled. That can raise your chances of isolating update related issues.
Have no clue about the picker, given that it worked till previous week (together with masks) i would try:
B1. disable GPU accelerations, or steps A1, A2
B2. make sure both my monitors run at the same Resolution.
People running OSX and Dual Monitor Setups with different resolutions have reported such issues. Usually the offset is the difference in resolution, which can be measurable with a screenshot and Photoshop Ruler in Pixels.
Definitely a silly coding fault, but they happen, often. So:
B3. Set both your monitors in the same resolution (even if you have to lower one’s) to see whether problem persists, if the resolution change is not that much (ie. 1920×1200 vs 1920×1080, which is about a vertical inch on a 24 monitor) and solves the problem, keep it.
And after doing all this you could have a guide of what to do and keep working till the problem is solved.