I had this issue whilst playing back prores files. It was my first project on a new machine and the problem was my sequence settings.
Right click your sequence in the project browser, then chose sequence settings.
Set your video previews settings to a suitable codec. I have mine set up as Quicktime (desktop) for the file format.
The problem with mine was the codec was set to AJA 10 bit RGB so I changed it to prores and now it works fine. You have to re-render your media though.
Regarding the raw 5D files, I’m not surprised. 5Ds (all Cannon SLRs) shoot in H.264 and the only NLE that I know of that can cope with H.264 playback is FCPX. Of course, that is a pretty horrid editing system! The general work flow for SLR shoots has always been, and to my mind still is, compress your rushes to Pro-res 422 (mac/quicktime users) before you do anything. It is the drawback of using a photographic camera.