Hey Josh,
The good news that unless you plan to replicate your Blu-ray disc, you won’t have to worry about region settings. This is because regional settings are applied at the replication stage and only at the replication stage. So if you are using Encore as your Blu-ray Authoring tool then you are good to go.
If you are looking to replicate your Blu-ray discs then you might want to look at a different Blu-ray Authoring tool.
Cheers,
Denny B.
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NetBlender DoStudio Blu-ray Team | https://dostudio.netblender.com | https://www.clearblu.org