Hi Dan,
thanks for your answer, but no, my comp and my pre-comp start both on ‘0’. Also, it seems more to be a glitch of the caching system. Or probably a combination between time remap and the caching system. I can clean all memory and cache and it turns to another combination then before. Also, hold keyframes are not respected. They suddenly change the blink to another frame. Very weird.
I just found this other thread and it seems the same problem, but on CS6. Is it possible that this never was addressed by Adobe?
https://forums.creativecow.net/thread/2/1042375
Edit:
I just found two solutions to this problem:
1. Render your pre-comp out and import the MOV-file again. If you have your mouth shapes or blinks as a video file the problem does not happen.
2. In your pre-comp open the composition settings with cmd+k (on a Mac) or ctrl+k (I suppose on windows) and open the advance tab. Select ‘Preserve Frame Rate when Nested‘. Then purge All Memory & Disk Cache (from the Edit/Purge option in the menu). This even works with several layers from PS or AI or what ever you have done to your pre-comp.
I really don’t know why, but both options have worked for me. Hopefully it works for someone else too.