I’m having the same issue!
I have a feeling it may be due to having installed the trial version of CS5 and then entering my company’s activation key, rather than waiting to install via the CDs that a co-worker was sitting on (who isn’t having any of these issues). In fact I got an email from Adobe yesterday telling me that my ‘free trial’ was almost over.
Photoshop randomly shuts down a LOT, and Adobe Acrobat isn’t working at all.
My updates to the software are up to date, but I’m thinking I may have to uninstall and reinstall with the disks.
Anyone have any solutions?