The LaCie S2S can handle HD Uncompressed.
Transfer rates will vary: Mac: up to 187MB/s; 64-bit PC: up to 160MB/s; 32-bit PC: up to 99MB/s**
This being said…I have seen with my own eyes the Mac Pro with AJA or Blackmagic showing a substained rate of 160. If you create the raid via the OS the Mac Pro shows a sustained rate of 200.
The interesting part is our S2S includes a PCI-E or PCI-X card offering 4 external eSATA ports. This will allow you to attach 4 S2S units and create a 10tb (4 x 2.5tb) raid “0” offering a sustained rate of 640 (4 x 160).
So yes it is possible to handle just about any HD uncompressed project you are or could be working with.
The cost? $2199.00 MSRP for each unit….