Very possible! Here’s the code for a script to do exactly as you describe. Let me know if you have any questions.
app.beginUndoGroup("Create guides");
var HORIZONTAL_GUIDE = 0;
var VERTICAL_GUIDE = 1;
app.project.activeItem.addGuide(HORIZONTAL_GUIDE, 10);
app.project.activeItem.addGuide(HORIZONTAL_GUIDE, app.project.activeItem.height - 10);
app.project.activeItem.addGuide(HORIZONTAL_GUIDE, app.project.activeItem.height / 2);
app.project.activeItem.addGuide(VERTICAL_GUIDE, 10);
app.project.activeItem.addGuide(VERTICAL_GUIDE, app.project.activeItem.width - 10);
app.project.activeItem.addGuide(VERTICAL_GUIDE, app.project.activeItem.width / 2);
app.endUndoGroup();