All depends what you want to use the quicktime for as well
A quicktime for approval, that a client wants to play on there laptop, after downloading from an ftp site, probably “shouldnt’ be the best quicktime in the world. It’ll most likely be too big to download, and quite possibly stutter on playback, which will cause the client to panic and call you up saying the show is not working properly.
When we get asked to output quicktimes, our first question is “what is it for”
If it is approval, we usually do H264, knowing the blacks might not be exactly the same, but good enough for approval, and playable by most client computers.
If it is to go to another suite as a “master” we would probably do uncompressed, or animation codec. Possibly an Avid compressed format, depending on the length of the program. 30 sec commercials at uncompressed are quite a bit smaller than 45 min broadcast length programs.
Glenn