I have an almost identical system to yours with a DL Extreme. What I have found is that the sound playback on the timeline can cause playback problems (strangely the video gives way to the sound so the video skips frames and goes out of sync)
My workaround is to render out the complete sound mix to a wav file and then bring it back into the timeline and mute all the others. Even better if you put the wav file on a separate drive to the video.
I have found the advantage of ‘video giving way to audio’ is when exporting to tape. I always set my sequence timecode to the same as the timecode on the tape I am exporting to. Then I can compare timecode cut points on the timeline with those on the master videotape. If they are not identical then I know a drop frame occurred somewhere. Having the same timecodes also helps in doing pick up edits.
Now the ‘dropframe somewhere’ can be a problem. It is a matter of going back in the timeline comparing it to the master until you find where it is back in sync. (go back a minute at a time to isolate the precise point)
A technique I use occasionally is to create an EDL prior to the export to tape and while exporting I put a VHS across the decks timecode displayed output and randomly play it back checking the cut points against the EDL. Obviously you wouldn’t bother with a short playout but I recently completed 3 x 90 min workout videos (boooorrrrring!) and wasn’t going to sit thru the whole lot checking for drop frame and lip sync errors; and I did have to stop a few times and pick up an edit when I detected an error on the VHS playback.